Evaluation of Blood Levels of C-Reactive Protein Marker in Obstructive Sleep Apnea: A Systematic Review, Meta?Analysis and Meta-Regression

(1) Introduction: High sensitivity C-reactive protein (hs-CRP) and CRP are inflammatory biomarkers associated with several diseases. In both pediatric adult individuals Obstructive Sleep Apnea (OSA) higher hs-CRP were observed, compared to controls. With the present systematic review, meta-analysis meta-regression we expand upon previous meta-analyses in four ways: We included 109 studies (96 adults 13 children); (2) reported subgroup analyses OSA controls on serum plasma levels of hs-CRP; (3) CRP; (4) children OSA, always Materials Methods: The PubMed/Medline, Scopus, Cochrane Library, Web Science databases searched retrieve articles published until 31 May 2020, no restrictions. data basic information involving first author, publication year, country study, ethnicity participants each age, BMI, AHI groups, mean standard deviation (SD) hs-CRP. Results: A total 1046 records retrieved from databases, selected for analysis reporting blood hs-CRP/CRP children). For adults, 11 hs-CRP, 44 9 CRP, 32 levels. children, 6 4 1 2 Compared controls, pooled MD was 0.11 mg/dL (p < 0.00001). 0.09 0.06 = 0.72). 0.36 1.17 0.005), 0.18 0.05), 0.08 0.10), 0.04 0.33), respectively. showed that a greater apnea-hypapnea index (AHI), significantly higher. Conclusions: results healthy level OSA; just